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KMID : 0376619920170020139
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Seoul Journal of Psychiatry
1992 Volume.17 No. 2 p.139 ~ p.148
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The Neurophysiological Basis of Basal Ganglia in Psychiatric Disorder
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Abstract
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Up to now the neurophysiological basis of psy chiatric disorders is, for the most part, unknown. Though the relationship between the dysfunction of basal ganglia and psychiatric disorders is also unknown, the possibility is confirmed by many
researchers. The suggestion is that the basal ganglia, acting as an active sensory gating role in CNS, maintain the normal flow of information processing. The dysfunction of the basal ganglia have been implicated in many psychiatric symptoms such
as
mood disturbance, delusion, hallucination, abnormal movement disorder and hypersensitivity. Such pychiatric symptom may, to a certain extent, represent a complex dysfunction of sensory filtering mechanism in the brain.
Recently many researchers are eager to brain imaging studies, using Positron emission tomography(PET), Single photon emission computed tomography (SPECT) and Magnetic resonance imaging (MRI), to confirm the functional and structural changes of
various
brain region including basal ganglia in vivo.
In this paper, the authors reviewed recent information about basal ganglia including neurophysiological aspects of it's connection system with other brain structure and related dysfunction in psychiatric disorders, especially schizophrenia and
depression.
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KEYWORD
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